Telomeres, Aging & How To Live Longer

Telomeres, Aging & How To Live Longer

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Telomeres, Aging & How To Live Longer
Subscribe for more awesome biomedical research: https://bit.ly/2SRMqhC Everything seems to become worse for our bodies the older we get. But what does aging mean in a biological context? And are there any ways to delay aging? Today we talk about cellular aging. Cellular aging is defined by the so called hallmarks of aging which include […]
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Subscribe for more awesome biomedical research: https://bit.ly/2SRMqhC

Everything seems to become worse for our bodies the older we get. But what does aging mean in a biological context? And are there any ways to delay aging?

Today we talk about cellular aging. Cellular aging is defined by the so called hallmarks of aging which include telomere attrition, stem cell arrest, cellular senescence and genomic instability among other factors. There is a lot of research being conducted in the fields of each of these hallmarks.

Our chromosomes are linear meaning they comprise two ends, respectively. In each of these ends we find telomeres (repetitive sequences; in humans they comprise TTAGGG). These repetitive sequences have a lot of crucial functions for the stability of our chromosomes. For instance, they form loops together with proteins in order to protect our chromosomes from being fused by our own DNA repair mechanisms. Furthermore, telomeres are the solution to the so called end-replication problem. The end-replication problem arises while we copy our DNA upon cell division. Every time we replicate our DNA, the very end of the chromosome cannot be fully copied resulting in a slow, gradual shortening of the chromosome. The enzyme telomerase can increase the lengths of telomeres by adding its repetitive sequence. However, telomerase is normally only highly active during early development and the older we get the shorter our telomeres become. There is a certain point at which our cells only comprise a fraction of its original telomere repetitions and they stop dividing.

There are many implications to replicative senescence such as stem cell exhaustion, which is another aspect of aging. Many age-related diseases are associated with the inability of these stem cells to divide. If, for instance, hematopoietic stem cells in our bone marrow become senescent, anemia and an impaired immune system can develop. If mesenchymal stem cells are affected osteoporosis and decreased fracture repair can occur.

Nobel laureate Elizabeth and her colleagues and found out that chronic stress can have a negative impact on telomerase activity and the lengths of chromosomes (in this study, it was found that mothers of chronically ill children have 48% less telomerase activity). Another studies investigated the relationship between telomere lengths and lifestyle changes in men with prostate cancer. These men had to under change their habits over a period of five years: They had to have a special diet high in whole foods and low in fat. They walked 6x a week for 30 minutes each. They started yoga and relaxation exercises and they formed a social support group which met 1 x a week. Not only were the telomere lengths of these men longer than those measured in a control group but they also slightly increased over time.

This gives us some hope that we can actually slow down telomere attrition through lifestyle changes leading to potential longer lives.

For your further research:

Epel, Elissa S., et al. “Accelerated telomere shortening in response to life stress.” Proceedings of the National Academy of Sciences 101.49 (2004): 17312-17315.
López-Otín, Carlos, et al. “The hallmarks of aging.” Cell 153.6 (2013): 1194-1217.
Ornish, Dean, et al. “Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study.” The lancet oncology 14.11 (2013): 1112-1120.

Music:
Intro:
Light Sting by Kevin MacLeod is licensed under a Creative Commons Attribution licence (https://creativecommons.org/licenses/…)
Source: http://incompetech.com/music/royalty-…
Artist: http://incompetech.com/
Transitions:
Light Thought var 3 by Kevin MacLeod is licensed under a Creative Commons Attribution licence (https://creativecommons.org/licenses/…)
Artist: http://incompetech.com/

About Clemens Steinek:
CLEMENS STEINEK is a postgraduate student/youtuber (LifeLabLearner) who is currently conducting stem cell research in Germany.

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How To Memorize Fast and Easily | 10 Important Tips & Tricks | Letstute
Check out our video on How to Memorize Fast and Easily | How to Memorize Quickly | Important Exam Tips For Students by Letstute This video gives 10 practical and effective tips for students to learn their subjects and Memorize the topics faster. Exam season is near, students face a lot of exam pressure and […]
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Mayo Clinic Minute: The diet that science shows could help you live longer

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Mayo Clinic Minute: The diet that science shows could help you live longer
Almost everyone has decided to go on a diet at some point in hopes of losing a few pounds and improving his or her health. With a nearly constant flow of new fad diets being pushed online and on social media, it can be difficult to know which diet will be most helpful for you. […]
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Island where people live longer than anyone on earth | 60 Minutes Australia

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Island where people live longer than anyone on earth | 60 Minutes Australia
In 2013 Liz Hayes visited the magical island where people live longer than anyone else on earth. They’re also happier and healthier. They have lower rates of cancer and heart disease and no dementia. So how do so many people live to be 100 and still tend their olive trees, drink lots of red wine […]
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How to Do Hip Lifts & Basic Shimmy | Belly Dancing

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How to Do Hip Lifts & Basic Shimmy | Belly Dancing
Like these Belly Dance Lessons !!! Check out the official app http://apple.co/1hu3Iir Beautiful Belly Dancing Accessories Hip Scarf (Short) with Gold Coins: http://amzn.to/1IBsoPG Tribal Chiffon Tiered Maxi Skirt: http://amzn.to/1PGOuAK Harem Pants: http://amzn.to/1RFbKTt Gold Sequined Bra Top: http://amzn.to/1JdM1h8 Gold Head Chain: http://amzn.to/1HhgGea Finger Cymbals: http://amzn.to/1F7CPYU Belly dancing Sword: http://amzn.to/1L2d8uR Chiffon Veil: http://amzn.to/1HdWIhB Face Veil: http://amzn.to/1cxlajf Bollywood […]
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Hypnosis for Weight Loss (Guided Relaxation, Healthy Diet, Sleep & Motivation)

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Hypnosis for Weight Loss (Guided Relaxation, Healthy Diet, Sleep & Motivation)
Download this track: https://michael-sealey.dpdcart.com/cart/add?product_id=92492&method_id=96924 My iTunes: https://itunes.apple.com/au/artist/michael-sealey/id921827456 CD Baby tracks: https://store.cdbaby.com/Artist/MichaelSealey Subscribe for more hypnosis: http://www.youtube.com/subscription_center?add_user=MichaelSealey Popular Playlists: 7 Day Self Hypnosis Personal Transformation Challenge: https://www.youtube.com/playlist?list=PLO9OtUmChpP_G2Tu_XPdT3I7M_My4HEI2 Sleep Hypnosis: https://www.youtube.com/playlist?list=PLO9OtUmChpP_Po7RGMHFJ4kNbavmHhYhJ Lucid Dreaming Hypnosis: https://www.youtube.com/playlist?list=PLO9OtUmChpP8M3iWPQtEl9fOZfvLOjxnK Hypnosis for Anxiety: https://www.youtube.com/playlist?list=PLO9OtUmChpP8mmOMo4zFsk7JeSxdEeZbt ……………………. Lose weight easily and naturally as you reprogram healthier diet habits with guided relaxation and positive suggestions […]
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Tips & Tricks to Save Money on Groceries + A Year of Deals | How I Shop & Stock Up | ASMR? 😂

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Tips & Tricks to Save Money on Groceries + A Year of Deals | How I Shop & Stock Up | ASMR? 😂
In-store discount grocery deals galore PLUS my last Aldi haul for 2019! I’ve been saving up my best deals from 2019 and compiled them all in this video to show you how I grocery shop WITHOUT COUPONS for my family of 4 (got a teenager and his friends! 😅) ON A BUDGET while I build […]
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SAVING MONEY IN 2020: how I saved $10,000 in 2019 | money saving tips & advice💰

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SAVING MONEY IN 2020: how I saved $10,000 in 2019 | money saving tips & advice💰
Hey ya’ll! Welcome to my channel! Today’s video is my first video of 2020! And more importantly – today’s video is going to be all about MONEY💰 With a new year, I thought it would be beneficial to tell you guys how I saved $10,000 in 2019 and things that you can implement in 2020 […]
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Money Saving Challenge 2020! Easy ways to save thousands! $5 Challenge & 2 Liter Challenge

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Money Saving Challenge 2020! Easy ways to save thousands! $5 Challenge  & 2 Liter Challenge
We’re starting off the year the right way. Come save money with us! Which Challenge would you do? -$5 Challenge? -$1 Challenge? -All Change Challenge? -Dime Challenge? ✅Learn how to get FREE FOOD at restaurants all you need is your phone! https://www.youtube.com/watch?v=ulMDO3Q3VLg&list=PL3WKc0BkN-Lv81a43h4F467gxOkPWtDnj ✅Learn how to find HIDDEN clearance at Walmart https://www.youtube.com/watch?v=byPTe9EUPtQ&list=PL3WKc0BkN-Lty0oK1Od8X-bK9x5tZW9L- ✅Sign up for FLUZ […]
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HOW TO MAKE A BUDGET + GET OUT OF DEBT! Tips & Tricks!

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HOW TO MAKE A BUDGET + GET OUT OF DEBT! Tips & Tricks!
HOW TO MAKE A BUDGET + GET OUT OF DEBT! Tips & Tricks! Try Amazon Prime FREE for 30 Days! https://amzn.to/2RjLcLz Cash Back Apps! Checkout51 Link: https://checkout51.app.link/bdCLSKiT2Q Sign Up for Fetch & Get 3,000 Points Using my Referral Code: JP5FY Ibotta Link: http://ibotta.sjv.io/c/1205919/518528/8841 Save BIG Online Shopping! Ebates Link: https://www.ebates.com/r/NATALI6770?eeid=28187 I’m a blogger and run […]
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HOW TO GET OUT OF DEBT: Where To Start & What Not To Do! | Ep.1

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HOW TO GET OUT OF DEBT: Where To Start & What Not To Do! | Ep.1
Most people will experience debt of some kind, and I hope in sharing this video, our tips and advice on how to manage and pay-off debt will assist you and relieve some stress off of the challenges of experiencing financial difficulties. •More Debt Solutions• If you’re struggling with debt, it can be hard to know […]
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Yoga for Weight Loss & Belly Fat, Complete Beginners Fat Burning Workout at Home, Exercise Routine

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Yoga for Weight Loss & Belly Fat, Complete Beginners Fat Burning Workout at Home, Exercise Routine
Yoga for Weight Loss & Belly Fat, Complete Beginners Fat Burning Workout at Home, Exercise Routine ♥ Our FREE Yoga App for Apple: https://apple.co/2MhqR8n ♥ Our FREE Yoga App for Android: https://bit.ly/2MidhBO ♥ Start Your Two Week Free Trail http://www.psychetruth.vhx.tv ♥ Help Support This Channel http://www.patreon.com/psychetruth ♥ Subscribe To Our Podcast http://wellnessplus.tv/podcast-audio/ #WellnessPlus #YogaWithSanela #YogaForWeightLoss […]
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how to french & ghost inhale! (joint hotbox)

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how to french & ghost inhale! (joint hotbox)
ty for watching Merch: https://teespring.com/stores/bentleyblazemerch Social Media insta: stfumatthew snapchat: matthewjbaileyy twitter: stfumatthew Bentley Blaze how to french & ghost inhale! (joint hotbox) how to do smoke tricks / tutorial
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